Mitochondrial and metabolic features of salugenesis and the healing cycle | Robert K. Naviaux (2023)

Abstract

Pathogenesis and salugenesis are the first and second stages of the two-stage problem of disease production and health recovery. Salugenesis is the automatic, evolutionarily conserved, ontogenetic sequence of molecular, cellular, organ system, and behavioral changes that is used by living systems to heal. It is a whole-body process that begins with mitochondria and the cell. The stages of salugenesis define a circle that is energy- and resource-consuming, genetically programmed, and environmentally responsive. Energy and metabolic resources are provided by mitochondrial and metabolic transformations that drive the cell danger response (CDR) and create the three phases of the healing cycle: Phase 1 — Inflammation, Phase 2 — Proliferation, and Phase 3 — Differentiation. Each phase requires a different mitochondrial phenotype. Without different mitochondria there can be no healing. The rise and fall of extracellular ATP (eATP) signaling is a key driver of the mitochondrial and metabolic reprogramming required to progress through the healing cycle. Sphingolipid and cholesterol-enriched membrane lipid rafts act as rheostats for tuning cellular sensitivity to purinergic signaling. Abnormal persistence of any phase of the CDR inhibits the healing cycle, creates dysfunctional cellular mosaics, causes the symptoms of chronic disease, and accelerates the process of aging. New research reframes the rising tide of chronic disease around the world as a systems problem caused by the combined action of pathogenic triggers and anthropogenic factors that interfere with the mitochondrial functions needed for healing. Once chronic pain, disability, or disease is established, salugenesis-based therapies will start where pathogenesis-based therapies end.

Graphical abstract

Commercial determinants of health | thelancet.com | vichealth.vic.gov.au (2023)

Published: March 23, 2023

Executive Summary

Commercial actors can contribute positively to health and society, and many do, providing essential products and services. However, a substantial group of commercial actors are escalating avoidable levels of ill health, planetary damage, and inequity — the commercial determinants of health. While policy solutions are available, they are not currently being implemented, and the costs of harm caused by some products and practices are coming at a great cost to individuals and society.

A new Lancet Series on the commercial determinants of health provides recommendations and frameworks to foster a better understanding of the diversity of the commercial world, potential pathways to health harms or benefits, and the need for regulatory action and investment in enterprises that advance health, wellbeing, equity, and society.

Reflections & Warnings – An Interview with Aaron Russo (2009)

In an historic final interview, filmmaker and music promoter Aaron Russo goes in depth on the insider-knowledge given to him by a member of the Rockefeller family. Russo was told (prior to 9/11) of plans to stage terror attacks, invade foreign nations, and kickstart a high-tech police state control grid that would track the populations’ every move with implantable R.F.I.D. microchips.

ENCYCLICAL LETTER LAUDATO SI’ OF THE HOLY FATHER FRANCIS ON CARE FOR OUR COMMON HOME

1. “LAUDATO SI’, mi’ Signore” – “Praise be to you, my Lord”. In the words of this beautiful canticle, Saint Francis of Assisi reminds us that our common home is like a sister with whom we share our life and a beautiful mother who opens her arms to embrace us. “Praise be to you, my Lord, through our Sister, Mother Earth, who sustains and governs us, and who produces various fruit with coloured flowers and herbs”.

2. This sister now cries out to us because of the harm we have inflicted on her by our irresponsible use and abuse of the goods with which God has endowed her. We have come to see ourselves as her lords and masters, entitled to plunder her at will. The violence present in our hearts, wounded by sin, is also reflected in the symptoms of sickness evident in the soil, in the water, in the air and in all forms of life. This is why the earth herself, burdened and laid waste, is among the most abandoned and maltreated of our poor; she “groans in travail” (Rom 8:22). We have forgotten that we ourselves are dust of the earth (cf. Gen 2:7); our very bodies are made up of her elements, we breathe her air and we receive life and refreshment from her waters.

What is Capitalism? A definition | Kate Raworth (@KateRaworth) March 6, 2023

Selected Talks on the Geopolitics of Global Peace, Security and Sustainable Development by Prof Jeffrey Sachs (2023)

Jeffrey Sachs is a world-renowned economics professor, bestselling author, and global leader in sustainable development. Sachs serves as the Director of the Center for Sustainable Development at Columbia University, where he holds the rank of University Professor. Sachs was the Director of the Earth Institute at Columbia University from 2002 to 2016. Prior to Columbia, Sachs spent over twenty years as a professor at Harvard University, including as the Galen L. Stone Professor of International Trade. Sachs has authored and edited numerous books, including three New York Times bestsellers: The End of Poverty (2005), Common Wealth: Economics for a Crowded Planet (2008), and The Price of Civilization (2011). He is the recipient of several international prizes and has advised several governments across the globe. Prof Sachs has also served as the Special Advisor to UN Secretaries-General Kofi Annan, Ban Ki-moon, and António Guterres.

THE EVOLUTIONARY EMERGENT OF UNIQUE SELF: A New Chapter in Integral Theory | Marc Gafni (2011)

ABSTRACT This article outlines the basic teachings of a new chapter in Integral Theory: the post-metaphysical evolutionary emergence of Unique Self. The article begins by contextualizing the Unique Self conversation within a larger discussion on individuality and traces the emergence of the Unique Self teachings through the life and writings of the author. The core Western understanding of individuality and its affirmation of the dignity of the separate self is contrasted with the Eastern teaching of dissolution of the small self, before both are integrated into a higher integral embrace through a new understanding of Unique Self. This article elucidates how the teachings of Unique Self fundamentally change the classical enlightenment paradigm through the assertion that enlightenment has a unique perspective, which might be termed the “personal face of essence.” Perspective taking, which emerges from enlightened consciousness, is rooted in the ontological pluralism that lies at the core of the Hebrew textual tradition. The new enlightenment teaching of Unique Self therefore rests on a series of integral discernments between separateness and uniqueness, ego and Unique Self, and personal and impersonal man. The Unique Self teaching suggests a new understanding of enlightenment through intersubjective love; the Unique Self perception is then set within an evolutionary context of being and becoming, in which it is seen to express one’s response to the personal address of the evolutionary God impulse itself. In this sense, Unique Self is understood to be an essential chapter in the emergence of a truly evolutionary mysticism.

KEY WORDS consciousness; ego; enlightenment; Integral Theory; Unique Self

Economies of Life: Patterns of Health and Wealth | Bill Sharpe (2010)

Economies of Life argues cogently that there is a ‘default assumption that there is only one economy in our lives – the economy which is the one based on money. Our position is that there are many economies, of which the one based on money is just one, and that they all contribute to the health and sustainability of our shared lives’. To extend this thinking, money is the currency of trade, and art is the currency of experience.

In his collection of five essays, Bill Sharpe uses the principles of ecological thinking to redefine our hitherto narrow understanding of terms like economy and value. The essays consider – with poetic sensitivity and intellectual clarity – what keeps each economy healthy, what sort of wealth each one accumulates and what sort of policies are most supportive of innovation and sustainability in a changing world.

Bill Sharpe and a small group of other IFF members, working with the Watershed Media Centre in Bristol, took as the starting point for their inquiry the question ‘Can we help people who fund the arts develop better policies if we use ecological thinking to understand how the arts work in society and in the economy?’

The insights resulting from Economies of Life offer an ecologically informed and dynamic framework for understanding creativity, the arts and how the arts should be funded into the future.

The Five Essays

Homo ecologicus, Homo economicus, Homo poeticus
Patterns of Shared Life
Art is the Currency of Experience
Economies of Life
Producing the Future

Ontology of Observing: The Biological Foundations of Self-Consciousness and of The Physical Domain of Existence | Humberto R. Maturana (1988)

My purpose in this essay is to explain cognition as a biological phenomenon, and to show, in the process, how language arises and gives origin to self consciousness, revealing the ontological foundations of the physical domain of existence as a limiting cognitive domain. In order to do this I shall start from two unavoidable experiential conditions that are at the same time my problems and my explanatory instruments, namely: a) that cognition, as is apparent in the fact that any alteration of the biology of our nervous system alters our cognitive capacities, is a biological phenomenon that must be explained as such; and b) that we, as is apparent in this very same essay, exist as human beings in language using language for our explanations. These two experiential conditions are my starting point because I must be in them in any explanatory attempt; they are my problems because I choose to explain them; and they are my unavoidable instruments because I must use cognition and language in order to explain cognition and language.

In other words, I propose not to take cognition and language as given unexplainable properties, but to take them as phenomena of our human domain of experiences that arise in the praxis of our living, and that as such deserve explanation as biological phenomena. At the same time, it is my purpose to use our condition of existing in language to show how the physical domain of existence arises in language as a cognitive domain. That is, I intend to show that the observer and observing, as biological phenomena, are ontologically primary with respect to the object and the physical domain of existence.

DELL ON MATURANA: A REAL FOUNDATION FOR FAMILY THERAPY? | Held, B. S., & Pols, E. (1987)

Two recent articles (Dell, 1985; Held & Pols, 1985a) have explored the problems created for the field of family therapy by a failure to use the term “epistemology” correctly – a failure that has produced a confusion between epistemology and ontology. The major problem is the contradiction of insisting, on the one hand, on the epistemological doctrine that there is no independent reality available to the knower and making, on the other hand, (ontological) claims about how the world really is (e.g., that the world operates by way of circular causality). This article examines Dell’s (1985) attempt, by appealing to Maturana’s doctrine of structure determinism, to resolve a version of this contradiction.