Mitochondrial and metabolic features of salugenesis and the healing cycle | Robert K. Naviaux (2023)

Abstract

Pathogenesis and salugenesis are the first and second stages of the two-stage problem of disease production and health recovery. Salugenesis is the automatic, evolutionarily conserved, ontogenetic sequence of molecular, cellular, organ system, and behavioral changes that is used by living systems to heal. It is a whole-body process that begins with mitochondria and the cell. The stages of salugenesis define a circle that is energy- and resource-consuming, genetically programmed, and environmentally responsive. Energy and metabolic resources are provided by mitochondrial and metabolic transformations that drive the cell danger response (CDR) and create the three phases of the healing cycle: Phase 1 — Inflammation, Phase 2 — Proliferation, and Phase 3 — Differentiation. Each phase requires a different mitochondrial phenotype. Without different mitochondria there can be no healing. The rise and fall of extracellular ATP (eATP) signaling is a key driver of the mitochondrial and metabolic reprogramming required to progress through the healing cycle. Sphingolipid and cholesterol-enriched membrane lipid rafts act as rheostats for tuning cellular sensitivity to purinergic signaling. Abnormal persistence of any phase of the CDR inhibits the healing cycle, creates dysfunctional cellular mosaics, causes the symptoms of chronic disease, and accelerates the process of aging. New research reframes the rising tide of chronic disease around the world as a systems problem caused by the combined action of pathogenic triggers and anthropogenic factors that interfere with the mitochondrial functions needed for healing. Once chronic pain, disability, or disease is established, salugenesis-based therapies will start where pathogenesis-based therapies end.

Graphical abstract

Read More

Commercial determinants of health | thelancet.com | vichealth.vic.gov.au (2023)

Published: March 23, 2023

Executive Summary

Commercial actors can contribute positively to health and society, and many do, providing essential products and services. However, a substantial group of commercial actors are escalating avoidable levels of ill health, planetary damage, and inequity — the commercial determinants of health. While policy solutions are available, they are not currently being implemented, and the costs of harm caused by some products and practices are coming at a great cost to individuals and society.

A new Lancet Series on the commercial determinants of health provides recommendations and frameworks to foster a better understanding of the diversity of the commercial world, potential pathways to health harms or benefits, and the need for regulatory action and investment in enterprises that advance health, wellbeing, equity, and society.

Read More

Words of Wisdom from Dr Zach Bush: On Humanity’s Awakening, Hope for Humanity & Finding Light in the Darkness | Luke Storey

Dr. Zach Bush is an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. He founded Seraphic Group and the nonprofit Farmer’s Footprint to develop root-cause solutions for human and ecological health. He sees that there is a dramatic need for a radical departure from chemical farming and pharmacy, and his ongoing efforts are providing a path for consumers, farmers, and mega-industries to work together for a healthy future for people and the planet.

So, really, there’s never been a better time to sit down with Dr. Bush — because our society and planet clearly need some help right now.

As you remember, Zach Bush MD is a physician specializing in internal medicine, endocrinology, and hospice care. He’s also an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. Our last conversation, which felt like an energy vortex of connectedness and truthfinding, episode 304, is one of my most streamed ever.

This week, he weaves at least a dozen thought patterns that might change your life forever. He is both flatly at peace with the end of all life and truthfully optimistic on our chances. You’re going to want to settle in for this one. Open your mind, and your notebook. Zach is a deep pool of mindblowing knowledge and perspective. I’m so excited to bring you this conversation.

Read More

Corporate Child Abuse: The Unseen Global Epidemic | Prof John McMurtry (2013)

“There can be no keener revelation of a society’s soul”, Nelson Mandela says, “than the way in which it treats its children”.

Who would disagree?

Yet today children may be assaulted, diseased, or killed by pervasive corporate drugs, junk-foods and beverages, perverted by mindless violence in multiple modes, deployed as dead-end labour with no benefits, and then dumped into a corporate future of debt enslavement and meaningless work. How could this increasing systematic abuse be publicly licensed at every level? What kind of society could turn a blind eye to its dominant institutions laying waste the lives of the young and humanity’s future itself?

The abuse is built into the system. All rights of child care-givers themselves – from parent workers to social life support systems – are written out of corporate ‘trade’ treaties which override legislatures to guarantee “investor profits” as their sole ruling goal. Children are at the bottom, and most dispossessed by the life-blind global system. The excuse of “more competitive conditions” means, in fact, a race to the bottom of wages and benefits for families, social security, debt-free higher education, and protections against toxic environments to which the young are most vulnerable. At the same time, escalating sales of junk foods, malnutrition, and cultural debasement propel the sole growth achieved – ever more money demand at the top.

Read More

Dr. Edward Bynum: Our African Unconscious: The Black Origins of Mysticism and Psychology (2021)

Are we a species at war with itself? What does our African unconscious reveal about all of us? Dr. Edward Bruce Bynum urges people to come together in his new book Our African Unconscious: The Black Origins of Mysticism and Psychology. Science, evolution, and deep religion all point us in the same direction. According to Dr. Bynum, ultimately, we must love each other or die.

He also a licensed psychologist and Diplomat in clinical psychology, and a senior fellow in the National Association for Applied Psychophysiology and Biofeedback. His focus is psychosomatic medicine, hypnosis and individual psychotherapy.

Read More

CORRECTIVE LENSES: HOW THE LAWS OF ENERGY NETWORKS IMPROVE OUR ECONOMIC VISION | SALLY GOERNER | World Futures (2013)

We face systemic problems — economic, political, social, and environmental ones all wound up together. Effective solutions are emerging in all of these domains, but we lack a reliable systemic perspective to weave them together. I believe Energy Network Science (ENS) can provide the sound, systemic framework we need to address our systemic problems. ENS’s study of the energy laws of growth and development can help restore our economies and our souls by: (1) Helping us rediscover the truth and power of free-enterprise democracy; (2) Giving us the tools and concepts we need to build healthy Democratic Free Enterprise Networks (DFENs), the kind that have always formed the sinews of American vitality; (3) Providing precise quantitative measures and targets for healthy development that seem quite unimaginable in the current milieu. This is the story of how these gifts change our view of how to rebuild economic vitality and restore the dream.

KEYWORDS: Balancing resilience & efficiency, energy network analysis, free enterprise democracy, quantitative measures of economic health, regenerative economics.

Read More

Innate Immune System | Zach Bush MD

There has never been a more important time to understand how your innate immune system functions. With a healthy immune system, we’re able to live in balance with the virome and array of flora that’s in every niche of our bodies. Join Zach Bush as he discusses The Innate Immune System.


The Innate Immune System webinar and live Q&A with Dr. Zach Bush, Dr. Cindy Fallon, Dr. John Gildea, Dr. Lee Cowden and Dr. Peter Cummings. In this two hour session, we broke down the intricacies and beauty of how our innate immune system functions and flows, unearthed empowering facts on the latest scientific findings on the virome, historical framing of germ warfare and how it applies to today’s mindset toward the pandemic and so much more from top experts across various fields within the human health realm.

Read More

The Hard Problem of Consciousness (2021) & The Neurobiological Underpinnings of Psychoanalytic Theory and Therapy (2018) | Prof Mark Solms

This paper sets out the neurobiological underpinnings of the core theoretical claims of psychoanalysis. These claims concern (1) innate emotional needs, (2) learning from experience, and (3) unconscious mental processing. The paper also considers the neurobiological underpinnings of the mechanisms of psychoanalytic treatment — a treatment which is based on the aforementioned claims. Lastly, it reviews the available empirical evidence concerning the therapeutic efficacy of this form of treatment.

Read More

The Virome: A Template for a Regenerative Future | Dr Zach Bush MD

What is the virome and how and why is it produced by the microbiome and human cells? In this 35 minute video, Dr. Zach Bush, M.D. elaborates on critical distinctions pertinent to human and planetary health as we look for solutions to respond to pandemic and endemic viruses. Learn how viruses have made the adaptive and resilient life that is exemplified in the mammals of our epoch, and how the toxins we’ve introduced on a massive scale create extinction level stress on the planet and ultimately destroy the fabric of this life within and around us. Ending the cycle of pollution is key to human and planetary health. Even though it may seem daunting, there is so much we can do to overcome these challenges and co-create a better future for our global community.

Read More