Attachment, Coherence, and the Conditions for Flourishing: A Cross-Scale Framework Linking Relational Neuroscience, Mitochondrial Bioenergetics, and Life-Value Governance | ChatGPT5 & NotebookLM

Human development relies on the capacity for co-regulation within relational environments. Modern attachment theory demonstrates that emotional security does not arise solely from individual psychological traits but from the nervous system’s ability to achieve and maintain physiological coherence in the presence of others. Concurrently, research in fascia, interoception, autonomic regulation, and mitochondrial bioenergetics shows that safety and stress are fundamentally embodied states that shape metabolic mode, immune signaling, and affective meaning-making. Secure attachment corresponds to flexible vagal regulation, oxidative mitochondrial metabolism, and balanced inflammatory tone, supporting learning, repair, and relational openness. Insecure and disorganized attachment correlate with chronic activation of the Cell Danger Response, autonomic dysregulation, inflammatory reactivity, and disruptions in interoceptive clarity, resulting in psychological distress and somatic illness.

At the societal scale, John McMurtry’s Life-Value Onto-Axiology provides a criterion for evaluating institutions: systems are life-coherent when they sustain the universal conditions required for life to flourish, and life-incoherent when they undermine those conditions. Extractive economic models, punitive governance, and social fragmentation can be understood as macro-scale expressions of attachment dysregulation and chronic threat physiology. Conversely, regenerative societies cultivate the ecological and relational conditions for earned secure attachment across development and adulthood.

This manuscript synthesizes attachment science, bioregulatory physiology, and life-value governance into an integrated coherence framework. It outlines clinical, educational, economic, and policy strategies for restoring conditions that support safety and relational trust, arguing that the future of human flourishing depends on designing systems that reliably regenerate coherence across biological, interpersonal, institutional, and ecological scales.

Healing Systems: Networks of Coherence (Volume 1) | ChatGPT5 & NotebookLM

This book redefines medicine, health, and governance as sciences of coherence. It introduces a minimalist yet universal grammar of five root tissues — fascia, endothelium, immune, neuroendocrine, and parenchyma — integrated with mitochondrial phase dynamics, oscillatory rhythms, the exposome, and the immunome.

Across the life course, health is sustained by rhythmic transitions and systemic coherence, while disease arises from stalls in these processes. Pathogenesis and salugenesis are reframed not as opposites but as complementary spirals: incoherence and re-coherence.

The book spans scales, from organelles to ecosystems, showing how the same coherence grammar applies to clinical healing, societal resilience, and planetary regeneration. Case studies, dashboards, endotype tables, and mandalas translate abstract principles into practical diagnostic and healing tools.

Ultimately, Healing Systems demonstrates that identifying and restoring coherence is the true art of medicine — for individuals, societies, and the Earth itself.

Toward a Life Coherent Regenerative Health Paradigm: Integrating Salutogenesis, Life Value Onto Axiology, and Salugenesis | ChatGPT4o

Contemporary health science has largely operated within the paradigm of pathogenesis, focusing on the mechanisms of disease. This paper proposes a comprehensive alternative that integrates three emerging frameworks: salutogenesis, John McMurtry’s life‑value onto‑axiology, and Robert K. Naviaux’s theory of salugenesis. Salutogenesis emphasises psychosocial resources and a sense‑of‑coherence that enables individuals to perceive life as comprehensible, manageable and meaningful. Life‑value onto‑axiology supplies a universal ethical criterion, asserting that a value is whatever expands the range of thought, felt‑being and action, and critiques life‑blind rationality that equates reason with self‑maximisation. Salugenesis describes the bottom‑up, energy‑intensive sequence of molecular, cellular and behavioural changes that constitute healing, highlighting the role of mitochondrial phenotypes and the cell danger response. Through comparative analysis, this paper identifies complementarities and gaps among these frameworks and synthesises them into a regenerative health model. The integrated model emphasises multi‑level interventions — supporting cellular healing, cultivating psychosocial coherence and grounding policy in life‑value ethics — and underscores the necessity of environmental stewardship for health. It concludes with practical implications for assessment, therapy and research, advocating for a paradigm that enables life across all domains.

The Life–Energy–Coherence Paradigm: Toward a Unified Science of Regenerative Health and Development | ChatGPT4o

The Life–Energy–Coherence Paradigm (LECP) presents a transformative framework for understanding health and human development, emphasizing coherence across biological, psychological, cultural, and ecological systems. This paradigm shifts the definition of health from merely the absence of disease to the dynamic realization of coherence, where energy and meaning are central to vitality and adaptation. At the core of LECP, mitochondria are identified as key decision-makers, responding to various signals from the environment and influencing healing and regeneration processes.

Core Premises and Insights

LECP posits that health emerges from the dynamic coherence of energy and meaning across multiple systems. This coherence is essential for vitality and adaptation, and disruptions in this coherence can lead to disease. Healing is redefined as the restoration of coherence, while regeneration refers to the emergence of new patterns that enhance life capacity. The paradigm integrates insights from various fields, including psychobiology, microbiome science, and ecological theory, to provide a holistic view of health.

Key Insights of LECP

Coherence is Health: Health is characterized by the integration of energy and meaning, rather than a static state.
Mitochondria as Decision Makers: Mitochondria play a critical role in sensing environmental signals and regulating growth and healing.
Microbiomes as Connectors: The gut and soil microbiomes are essential for maintaining mitochondrial function and overall health.
Sense of Coherence (SOC): A high SOC enables individuals to navigate stress effectively, promoting healing and resilience.

Implications for Health Practices

LECP advocates for a shift in health practices from merely managing symptoms to restoring coherence. This involves focusing on enhancing life capacities, integrating emotional coherence into education, and rebuilding civil commons that support health and wellbeing. In education, curricula should emphasize emotional coherence and connection to nature, while policies should prioritize access to essential life resources.

Transformative Approaches

Health Practice: Transition from symptom control to coherence restoration.
Education: Center on emotional coherence and nature.
Policy: Rebuild civil commons for equitable access to resources.

Theoretical Foundations

LECP is grounded in several theoretical frameworks, including Life-Value Onto-Axiology (LVOA), which assesses systems based on their ability to enhance life capacities. Integral Theory (AQAL) maps human experiences across dimensions, while the Salutogenic model focuses on what promotes health amidst stress. These frameworks collectively inform the understanding of coherence as a multi-dimensional phenomenon that requires integration across individual, collective, and ecological levels.

Mitochondrial Health and Healing

Mitochondria are central to the LECP, serving as bioenergetic regulators that influence cellular responses to stress and healing processes. The Energy Resistance Principle (ERP) posits that optimal energy resistance is crucial for maintaining health, while disruptions can lead to chronic illness. Healing involves a cyclical process where cells transition through phases of defense, rebuilding, and reintegration.

Conclusion: A Call to Action

The LECP emphasizes the need for a paradigm shift in how health is understood and practiced. It calls for a reweaving of the fabric of life, where coherence is prioritized across all systems. By recognizing the interconnectedness of health, ecology, and society, the LECP fosters a regenerative approach that aligns individual and collective wellbeing with the rhythms of life. This holistic perspective invites practitioners, educators, and policymakers to engage in practices that support the emergence of a more coherent and regenerative civilization.

A SMART approach to One Love and One Health: A ChatGPT4o explication of an emerging, integrative perspective that transcends and includes the processes of energy conservation and stress mitigation grounded in safe, stable, and nurturing relationships and life-value onto-axiological principles

Goal: Reduce chronic stress and improve overall health in a selected community by integrating One Health and One Love principles over the next 3 years.

Specific: Implement community-based health programs that address human, animal, and environmental health, and promote social cohesion through inclusive activities.
Measurable: Track the reduction in chronic stress indicators (e.g., cortisol levels, self-reported stress), improvements in health outcomes (e.g., reduced incidence of stress-related illnesses), and community engagement levels.
Achievable: Secure funding, partner with local health and social organizations, and utilize existing community resources.
Relevant: Addresses interconnected health issues and promotes a supportive community environment, aligning with the BEC, CDR, and life-value compass principles.
Time-bound: Roll out the program within 6 months, with ongoing monitoring and a comprehensive review after 3 years.

By setting SMART goals, these insights can be translated into concrete actions that foster safe, secure, and nurturing relationships, ultimately leading to societal transformation.

Mitochondrial and metabolic features of salugenesis and the healing cycle | Robert K. Naviaux (2023)

Abstract

Pathogenesis and salugenesis are the first and second stages of the two-stage problem of disease production and health recovery. Salugenesis is the automatic, evolutionarily conserved, ontogenetic sequence of molecular, cellular, organ system, and behavioral changes that is used by living systems to heal. It is a whole-body process that begins with mitochondria and the cell. The stages of salugenesis define a circle that is energy- and resource-consuming, genetically programmed, and environmentally responsive. Energy and metabolic resources are provided by mitochondrial and metabolic transformations that drive the cell danger response (CDR) and create the three phases of the healing cycle: Phase 1 — Inflammation, Phase 2 — Proliferation, and Phase 3 — Differentiation. Each phase requires a different mitochondrial phenotype. Without different mitochondria there can be no healing. The rise and fall of extracellular ATP (eATP) signaling is a key driver of the mitochondrial and metabolic reprogramming required to progress through the healing cycle. Sphingolipid and cholesterol-enriched membrane lipid rafts act as rheostats for tuning cellular sensitivity to purinergic signaling. Abnormal persistence of any phase of the CDR inhibits the healing cycle, creates dysfunctional cellular mosaics, causes the symptoms of chronic disease, and accelerates the process of aging. New research reframes the rising tide of chronic disease around the world as a systems problem caused by the combined action of pathogenic triggers and anthropogenic factors that interfere with the mitochondrial functions needed for healing. Once chronic pain, disability, or disease is established, salugenesis-based therapies will start where pathogenesis-based therapies end.

Graphical abstract

From Environmental Toxicants to the Cell Danger Response of Chronic Diseases to the Healing Cycle | Prof Robert Naviaux

The pace of change in the human ecosystem has accelerated rapidly in the past 30 years. These changes not only affect human health, but the health of plants and animals that share the environment with us. Nine keystone vertebrate, invertebrate and plant species have experienced extinctions or population crashes since the 1980s, and opportunistic human infections are on the rise. These crashes and infections can be traced to changes in metabolism that underlie epigenetics, innate, and adaptive immunity. Epigenetic and immunologic ripple effects have led to new Acquired Immunodeficiency Syndromes (AIDS) in plants and animals, and Acquired Autoimmune Disorders (AAIDS) in humans and domesticated animals. Autism is one of nearly a dozen new, neuroimmune and metabolic spectrum disorders (NIMS) that have emerged as a consequence of these new combinations of environmental factors that have never before been encountered by the human genome. This talk will showcase examples of AIDS, AAIDS, and NIMS that teach us about the unintended, and often-invisible environmental changes caused by human technological progress, and how these changes can be measured and managed systematically.