From Natural Drift to Evolutionary Living Coherence: A Maturanan Framework for Evo-Devo, Niche Construction, Symbiosis, Inheritance, and Population Genetics | ChatGPT-5.5 Thinking and NotebookLM

Humberto Maturana and Jorge Mpodozis’s theory of natural drift reframes evolution as the historical conservation and diversification of organism–niche relations rather than as the direct optimization of organisms by external selection. This white paper develops natural drift in dialogue with contemporary evolutionary biology, including the Extended Evolutionary Synthesis, evolutionary developmental biology, developmental plasticity, niche construction, symbiosis, holobiont theory, inclusive inheritance, epigenetic inheritance, and population genetics. The central thesis is that evolution can be understood as the historical conservation, transformation, and diversification of viable ways of living. In this framing, development generates phenotype–niche possibilities; behavior guides organism–niche relations; plasticity enables structural coupling in ontogenic time; niche construction modifies the conditions of future evolution; symbiosis expands the organism beyond the host genome; inheritance transmits more than DNA; and population genetics describes the genetic stabilization, sorting, and transformation of variation across generations. Natural selection remains indispensable, but it is interpreted as one sorting process within the wider historical drift of living coherence. This synthesis does not reject the Modern Synthesis; it situates it within a broader relational biology of organism, niche, lineage, and biosphere.

From Autopoiesis to Living Coherence: A Maturanan Biological Framework for Disease, Healing, and Non-Forcing Action | ChatGPT-5.5 Thinking and NotebookLM

Humberto Maturana’s biology of cognition offers a rigorous non-reductionist account of living systems as autonomous, structurally determined, autopoietic unities that conserve themselves through ongoing structural coupling with their medium. This white paper develops a Maturanan biological framework for understanding disease, healing, and non-forcing action. It proposes the concept of living coherence to describe the dynamic conservation of congruence among the nested processes through which a living system maintains viable organism–niche relations. These processes include metabolic and mitochondrial regulation, redox signaling, immune tolerance and repair, neuroendocrine-affective regulation, microbiome ecology, developmental plasticity, behavior, social relations, and ecological context. Within this framework, health is interpreted as the dynamic conservation of viable coupling; disease as costly conserved drift, loss of congruence, or collapse of organism–niche viability; and healing as the restoration or reorganization of viable structural coupling. The paper draws on Maturana’s concepts of autopoiesis, structural coupling, cognition, emotioning, love, and natural drift, and places them in dialogue with contemporary work in allostasis, mitochondrial psychobiology, redox biology, organism-centered immunology, microbiome science, affective neuroscience, evo-devo, and enactive cognition. The resulting framework supports a biological interpretation of non-forcing action: intervention as careful, congruent perturbation that respects the autonomy of living systems and enlarges their field of viable possibilities.

Natural Drift and the Future of Medicine | ChatGPT-5.5 Thinking and NotebookLM

Modern medicine is reaching the limits of a disease-centered paradigm when confronted by chronic disease, antimicrobial resistance, zoonotic risk, metabolic illness, mental distress, ecological degradation, climate vulnerability, social fragmentation, and widening inequity. These crises cannot be adequately understood as isolated biological malfunctions, nor as external “determinants” added around the individual body. They arise from historically conserved ways of living that have reshaped the relations among human beings, animals, plants, microbes, ecosystems, institutions, technologies, economies, and planetary systems.

This white paper develops a Maturana-informed account of natural drift as a conceptual foundation for rethinking medicine within the biosphere–anthroposphere unity. Rather than viewing evolution as adaptation to a pre-given environment, Maturana’s concept of natural drift emphasizes the historical conservation and transformation of organism–niche relations. Extended to human civilization, this insight suggests that societies drift according to the conversations, emotions, institutions, technologies, practices, and desires they conserve.

The paper argues that medicine must now be situated within this larger drift. Human civilization has become a planetary niche-making force, and its conserved patterns increasingly shape the health of persons, communities, animals, plants, microbes, ecosystems, and future generations. One Health provides the operational framework for recognizing the interdependence of human, animal, plant, microbial, ecosystem, and institutional health. The Field of Viability Framework provides the diagnostic grammar for assessing how constraints, margins, state, disturbance, perception, regulation, and options preserve or erode life-capacity.

The paper proposes that the future of medicine lies in becoming a reflective and practical discipline of life-coherent drift: rescuing the acutely ill, restoring organism–niche coherence, preventing the production of avoidable suffering, coordinating One Health action, and helping civilization consciously conserve the conditions in which life can continue to bring forth life. This does not displace acute biomedical care or make clinicians responsible for civilization as a whole; rather, it situates rescue, chronic care, public health, One Health, and policy guidance within a shared responsibility for conserving life-capacity.

Where is the organism? drifts and other histories in biology and in immunology | Nelson Vaz et. al | 2011

This compilation of essays brings together fundamental reflections on the historical drift of living systems and the immune system. As such, this book – like any foray that makes use of a biological look – essentially deals with organisms and histories. Yes, that seems obvious. Inescapable. And it is at the heart of what is obvious that the texts that follow explain and reaffirm. So, at the same time that we notice the triviality of talking about organisms and histories every time it comes to Biology, we are surprised to realize that the most common way of asking questions in contemporary Biology buries these two concepts. It is because, when presenting an organism that lives crushed between two forces: the first coming from random genetic mutations, and the second arising from the selective pressures of a threatening environment, this official way of raising questions about the natural world creates an organism that is determined and hostage to its genes. So, based on this condition, we talk about information replicators, and pre-formation and adult-centered explanations are accepted, apparently without problems, as shown in the first paragraph of an important book, Darwinian Medicine: “If a DNA strand can code the plans for the adult organism, why are we unable to regenerate a lost finger?” (NESSE; WILLIAMS, 1994); or, yet, statements like the one that appears highlighted in a colored text box in the middle of a recent article in the journal Nature: “It is an intriguing idea that you can peel your genome and reveal your future” (PEARSON, 2008). That is to say, in this explanation centered on the genes, it does not matter the history that happens in the living of the organisms, which, incidentally, there are not even seen as a relevant problem, because they are mere carriers of the information genes and passive responders of cruelty of a natural environment very similar to British society. It seems that the question of “how are organisms reproduced (produced again) each generation” has historically been replaced by a question about “where is the information that is transmitted to the offspring”. One asks for nouns instead of verbs, and with that one answers: “molecules (metaphysics) of life” instead of processes of living. And, with this way of asking, biology arises exaggeratedly focused only on two problems: 1) on the genome of organisms, thus making development unnecessary, the dynamics that would make it possible to explain the dynamic construction of living beings; and 2) in adult living, in which the issues of the struggle for sex and survival can be shown more easily in some specific cases of mammals. Together, these two arguments create a very deep gap between fertilization and the adult individual, already produced and looking for sex and food.

The origin of species by means of natural drift | HUMBERTO MATURANA-ROMESIN & JORGE MPODOZIS | 2000

ABSTRACT

In this article we propose that the mechanism that gave rise to the diversity of living systems that we find today, as well as to the biosphere as coherent system of interrelated autonomous living systems, is natural drift. And we also propose that that which we biologists connote with the expression natural selection is a consequence of the history of the constitution of the biosphere through natural drift, and not the mechanism that generates that history. Moreover, we do this by proposing: a) that the history of living systems on earth is the history of the arising, conservation, and diversification of lineages through reproduction, and not of populations; b) that biological reproduction is a systemic process of conservation of a particular ontogenic- phenotype/ontogenic- niche relation, and not a genetic process of conservation of some genetic constitution; c) that a lineage arises in the systemic reproductive conservation of an ontogenic-phenotype/ontogenic-niche relation, and not in the conservation of a particular genotype; d) that although nothing can happen in the life history of a living system that is not permitted by its total genotype, whatever happens in it arises in an epigenetic manner, and it is not possible to properly claim that any features that arises in the life history of an organism is genetically determined; e) that it is behavior what guides the course of the history of living systems, not genetics; and f) that that which a taxonomist distinguishes when he or she claims that an organism belongs to a particular species, is a particular ontogenic phenotype/ontogenic niche relation that occupies a nodal position in the historical diversification of lineages.